As history would suggest, the position of running back is one that largely shifts and changes due to a variety of factors as the NFL regular season wears on.

This season is obviously no different with a bevy of once-prominent ball carriers now off the field heading into Week 6. It’s also been a trying start to the season for many of the game’s top backs, as players like Matt Forte and Eddie Lacy started slow but should be in for big games this weekend.

The injuries have also paved the way for potential breakout stars to emerge this week. Backup rookies Branden Oliver of San Diego and Andre Williams of the New York Giants will receive golden opportunities after Donald Brown and Rashad Jennings went down with injuries in Week 5.

But at the end of the day, the true workhorses still sit atop the fantasy rankings as the most consistent, making them even more invaluable on the virtual gridiron. Here are our Top 25 running backs for Week 6 of the 2014 regular season: